Product Description: cytochrome c, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005758 | mitochondrial intermembrane space |
| Component | GO:0005746 | mitochondrial respirasome |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0009055 | electron transfer activity |
| Process | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen |
| Process | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.30 | 0.85 |
| Trophozoite | expressed | 0.73 | 0.60 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.53 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1404100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.125 | MFS: -3.201 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1038000)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1038000)
Modification: Other | RMgm-409
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM53
"Best" AlphaFill ligand hit: T3Y (25,26,27,28-tetrahydroxypentacyclo[19.3.1.1~3,7~.1~9,13~.1~15,19~]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-5,11,17,23-tetrasulfonic acid, Local RMSD=0.03) with 4YE1 (Global RMSD=0.60)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101063
Most Similar Human Ortholog: P99999
TM-align score: 0.97 | RMSD: 0.54
Seq Identity: 0.64 | Length: 104 / 115
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000172115 | cytochrome c, somatic |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 63
Non-coding: 60 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 115 | Molecular Weight (kDa): 12.894
UniProt ID(s): Q8IM53
PDB ID(s): None
Isoelectric Point: 9.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002327 | Cytochrome c, class IA/ IB |
| InterPro | IPR009056 | Cytochrome c-like domain |
| InterPro | IPR036909 | Cytochrome c-like domain superfamily |
| PFam | PF00034 | Cytochrome c-like domain |
| Superfamily | SSF46626 | Cytochrome c-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |