PF3D7_1404300 (SOAP)

Genome location: Pf3D7_14_v3:150,000..150,608(+)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete adhesive protein, putative

SignalP Peptide: MKNFTCFFLLTLLLTLAYG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020009	microneme

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.01	0.99
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1404300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.996 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1037800)

Relative Growth Rate: 1.00 ± 0.01
Confidence: 10.00

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1040200)

Modification: Tagged | RMgm-5053

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM51

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533594

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	6	14
disruptive	13	16	14	22
missense	8	4	10	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	27	15	12
disruptive	18	41	27	57
missense	9	23	21	37

PlasmoDB Total SNPs: 29

Non-coding: 0 | Synonymous: 17 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 202 | Molecular Weight (kDa): 22.734

UniProt ID(s): Q8IM51

PDB ID(s): None

Isoelectric Point: 4.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12828632	SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion andoocyst development.	Dessens JT, Siden-Kiamos I, ..., Sinden RE	10.1046/j.1365-2958.2003.03566.x