Product Description: ribosomal protein L16, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000311 | plastid large ribosomal subunit |
| Function | GO:0019843 | rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0032543 | mitochondrial translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.13 | 0.92 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1404400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.153 | MFS: -2.839 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1037700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM50
"Best" AlphaFill ligand hit: UGA (udp-glucuronic acid, Local RMSD=0.84) with 3GG2 (Global RMSD=17.24)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101573
Most Similar Human Ortholog: E9PI14
TM-align score: 0.84 | RMSD: 1.80
Seq Identity: 0.27 | Length: 84 / 181
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166902 | mitochondrial ribosomal protein L16 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 10 | 16 |
| disruptive | 3 | 12 | 14 | 23 |
| missense | 3 | 12 | 14 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 22 | 9 | 14 |
| disruptive | 5 | 43 | 19 | 45 |
| missense | 3 | 37 | 16 | 30 |
PlasmoDB Total SNPs: 102
Non-coding: 95 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 181 | Molecular Weight (kDa): 20.501
UniProt ID(s): Q8IM50
PDB ID(s): None
Isoelectric Point: 10.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000114 | Ribosomal protein L16 |
| InterPro | IPR016180 | Ribosomal protein L10e/L16 |
| InterPro | IPR036920 | Ribosomal protein L10e/L16 superfamily |
| PFam | PF00252 | Ribosomal protein L10e/L16 |
| Superfamily | SSF54686 | Ribosomal protein L10e/L16 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |