Product Description: rRNA biogenesis protein RRP5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0032040 | small-subunit processome |
| Function | GO:0003723 | RNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.89 | 0.60 |
| Trophozoite | expressed | 0.65 | 0.65 |
| Schizont | expressed | 0.14 | 0.92 |
| Gametocyte | not expressed | 0.47 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1404500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -2.912 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1037600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1037600)
Modification: Disrupted | RMgm-2900
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM49
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100538
Most Similar Human Ortholog: Q14690
TM-align score: 0.60 | RMSD: 3.50
Seq Identity: 0.31 | Length: 314 / 468
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148843 | programmed cell death 11 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 23 | 15 | 28 |
| disruptive | 25 | 72 | 33 | 89 |
| missense | 11 | 50 | 20 | 61 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 42 | 26 | 30 |
| disruptive | 42 | 144 | 61 | 145 |
| missense | 18 | 97 | 43 | 93 |
PlasmoDB Total SNPs: 111
Non-coding: 34 | Synonymous: 41 | Nonsynonymous: 36 | Stop Codon: 0
Protein Length: 468 | Molecular Weight (kDa): 56.262
UniProt ID(s): Q8IM49
PDB ID(s): None
Isoelectric Point: 9.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003107 | HAT (Half-A-TPR) repeat |
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16524898 | Saccharomyces cerevisiae Sof1p associates with 35S Pre-rRNA independent from U3snoRNA and Rrp5p | Bax R, Vos HR, Raue HA, Vos JC | 10.1128/EC.5.3.427-434.2006 |
| 16428605 | Rrp5p, a trans-acting factor in yeast ribosome biogenesis, is an RNA-bindingprotein with a pronounced preference for U-rich sequences | de Boer P, Vos HR, ..., Raue HA | 10.1261/rna.2257606 |
| 36340339 | Artificial optimization of bamboo Ppmar2 transposase and host factors effects onPpmar2 transposition in yeast | Zhou X, Xie J, ..., Zhou M | 10.3389/fpls.2022.1004732 |
| 15590824 | Deletion of the three distal S1 motifs of Saccharomyces cerevisiae Rrp5pabolishes pre-rRNA processing at site A(2) without reducing the production offunctional 40S subunits | Vos HR, Faber AW, ..., Raue HA | 10.1128/EC.3.6.1504-1512.2004 |