Genome location: Pf3D7_14_v3:154,855..160,386(-)
Genome classification: Core
Product Description: adenylyl cyclase alpha
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: 4.6.1.1 (Adenylate cyclase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0004016 | adenylate cyclase activity |
| Process | GO:0006171 | cAMP biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | nd | nd |
| Trophozoite | not expressed | nd | nd |
| Schizont | not expressed | nd | nd |
| Gametocyte | possibly expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1404600.3
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.864 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A0Z1
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=14.94) with 2CDU (Global RMSD=18.00)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 51 | 23 | 44 |
| disruptive | 7 | 78 | 40 | 100 |
| missense | 7 | 76 | 40 | 93 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 97 | 41 | 36 |
| disruptive | 29 | 143 | 70 | 174 |
| missense | 23 | 126 | 64 | 129 |
PlasmoDB Total SNPs: 344
Non-coding: 307 | Synonymous: 29 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 865 | Molecular Weight (kDa): 104.215
UniProt ID(s): A0A144A544, Q7Z1B9, Q8I7A1
PDB ID(s): None
Isoelectric Point: 9.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| InterPro | IPR029787 | Nucleotide cyclase |
| PFam | PF00211 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Superfamily | SSF55073 | Nucleotide cyclase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 7263625 | Glycophosphoceramides from plants. Purification and characterization of a noveltetrasaccharide derived from tobacco leaf glycolipids | Hsieh TC, Lester RL, Laine RA | https://pubmed.ncbi.nlm.nih.gov/7263625/ |
| 18389080 | Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apicalregulated exocytosis and hepatocyte infection | Ono T, Cabrita-Santos L, ..., Rodriguez A | 10.1371/journal.ppat.1000008 |