About Gene List

PF3D7_1404700

Genome location: Pf3D7_14_v3:160,928..162,542(-)

Genome classification: Core

Function and Localization

Product Description: cysteine-rich small secreted protein CSS, putative

SignalP Peptide: MIKVLLAVLFILIKLENIIG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0071944 cell periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.95
Trophozoite not expressed 0.00 1.00
Schizont possibly expressed 0.03 0.98
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1404700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.192 | MFS: -3.297 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM47

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533138

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 16 9 25
disruptive 13 17 7 13
missense 13 16 7 9

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 30 11 22
disruptive 22 30 14 62
missense 22 21 12 36

PlasmoDB Total SNPs: 87

Non-coding: 65 | Synonymous: 9 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 290 | Molecular Weight (kDa): 33.352

UniProt ID(s): Q8IM47

PDB ID(s): None

Isoelectric Point: 6.97

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23950716 Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. Heiber A, Kruse F, ..., Spielmann T 10.1371/journal.ppat.1003546