About Gene List

PF3D7_1404800

Genome location: Pf3D7_14_v3:163,283..168,162(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 2.12 0.21
Trophozoite expressed 0.52 0.74
Schizont expressed 0.35 0.80
Gametocyte expressed 0.31 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1404800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.062 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A3F9

"Best" AlphaFill ligand hit: GNP (phosphoaminophosphonic acid-guanylate ester, Local RMSD=24.64) with 3R7W (Global RMSD=20.29)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533640

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 53 32 72
disruptive 41 208 112 214
missense 26 186 109 188

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 105 43 98
disruptive 89 411 167 324
missense 61 371 144 214

PlasmoDB Total SNPs: 236

Non-coding: 128 | Synonymous: 61 | Nonsynonymous: 46 | Stop Codon: 1

Protein Information

Protein Length: 954 | Molecular Weight (kDa): 112.797

UniProt ID(s): A0A144A3F9

PDB ID(s): None

Isoelectric Point: 7.23

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23950716 Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. Heiber A, Kruse F, ..., Spielmann T 10.1371/journal.ppat.1003546
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g