Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: MLSVNKVTALLFFYILLIKGYYGRTES
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0005737 | cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.06 | 0.24 |
| Trophozoite | expressed | 1.47 | 0.32 |
| Schizont | expressed | 0.70 | 0.60 |
| Gametocyte | possibly expressed | 1.88 | 0.21 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1404900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.738 | MFS: -3.131 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1037300)
Modification: Tagged | RMgm-1482
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM45
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 221
Non-coding: 214 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 297 | Molecular Weight (kDa): 34.725
UniProt ID(s): Q8IM45
PDB ID(s): None
Isoelectric Point: 8.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23950716 | Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. | Heiber A, Kruse F, ..., Spielmann T | 10.1371/journal.ppat.1003546 |
| 27371728 | Proteomic Analysis of the Plasmodium berghei Gametocyte Egressome and VesicularbioID of Osmiophilic Body Proteins Identifies Merozoite TRAP-like Protein (MTRAP)as an Essential Factor for Parasite Transmission. | Kehrer J, Frischknecht F, Mair GR | 10.1074/mcp.M116.058263 |