PF3D7_1405100

Genome location: Pf3D7_14_v3:175,043..179,843(-)

Genome classification: Core

Function and Localization

Product Description: GTPase-activating protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005096	GTPase activator activity
Process	GO:0090630	activation of GTPase activity
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.22	0.89
Trophozoite	expressed	0.49	0.72
Schizont	possibly expressed	0.52	0.71
Gametocyte	not expressed	0.67	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1405100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.027 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM43

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532390

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	45	28	71
disruptive	26	135	91	178
missense	20	120	81	149

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	100	53	69
disruptive	55	303	114	284
missense	36	264	98	198

PlasmoDB Total SNPs: 257

Non-coding: 95 | Synonymous: 109 | Nonsynonymous: 50 | Stop Codon: 3

Protein Information

Protein Length: 1157 | Molecular Weight (kDa): 139.479

UniProt ID(s): Q8IM43

PDB ID(s): None

Isoelectric Point: 5.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000195	Rab-GTPase-TBC domain
InterPro	IPR035969	Rab-GTPase-TBC domain superfamily
PFam	PF00566	Rab-GTPase-TBC domain
Superfamily	SSF47923	Rab-GTPase-TBC domain superfamily