Product Description: trafficking protein particle complex subunit 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030008 | TRAPP complex |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | not expressed | 0.34 | 0.79 |
| Schizont | not expressed | 0.17 | 0.88 |
| Gametocyte | not expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1405200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.18 | MFS: -2.632 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM42
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102947
Most Similar Human Ortholog: I3L3S0
TM-align score: 0.84 | RMSD: 1.75
Seq Identity: 0.28 | Length: 89 / 192
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170043 | trafficking protein particle complex 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 9 | 6 | 10 |
| disruptive | 4 | 22 | 13 | 35 |
| missense | 4 | 21 | 13 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 13 | 17 |
| disruptive | 10 | 43 | 26 | 54 |
| missense | 7 | 42 | 21 | 32 |
PlasmoDB Total SNPs: 93
Non-coding: 88 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 192 | Molecular Weight (kDa): 22.779
UniProt ID(s): Q8IM42
PDB ID(s): None
Isoelectric Point: 9.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007233 | Trafficking protein particle complex subunit |
| InterPro | IPR011012 | Longin-like domain superfamily |
| PFam | PF04099 | Trafficking protein particle complex subunit |
| Superfamily | SSF64356 | Longin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24961828 | Crystal structure of the yeast TRAPP-associated protein Tca17 | Wang C, Gohlke U, Roske Y, Heinemann U | 10.1111/febs.12888 |