PF3D7_1405300

Genome location: Pf3D7_14_v3:181,855..185,353(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005759	mitochondrial matrix
Component	GO:0005634	nucleus
Function	GO:0003896	DNA primase activity
Function	GO:0003887	DNA-directed DNA polymerase activity
Function	GO:0003682	chromatin binding
Process	GO:0006264	mitochondrial DNA replication
Process	GO:0031297	replication fork processing
Process	GO:0009411	response to UV
Process	GO:0019985	translesion synthesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.24	0.88
Trophozoite	not expressed	0.47	0.72
Schizont	not expressed	0.28	0.81
Gametocyte	not expressed	0.42	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1405300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.403 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM41

"Best" AlphaFill ligand hit: DTP (, Local RMSD=0.33) with 5L2X (Global RMSD=6.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105020

Most Similar Human Ortholog: D6R971

TM-align score: 0.53 | RMSD: 2.57

Seq Identity: 0.14 | Length: 64 / 1025

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000164306	primase and DNA directed polymerase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	48	35	47
disruptive	41	178	105	240
missense	28	149	95	210

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	103	45	65
disruptive	76	389	189	297
missense	48	329	161	216

PlasmoDB Total SNPs: 133

Non-coding: 35 | Synonymous: 51 | Nonsynonymous: 47 | Stop Codon: 0

Protein Information

Protein Length: 1025 | Molecular Weight (kDa): 124.102

UniProt ID(s): Q8IM41

PDB ID(s): None

Isoelectric Point: 6.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	PF03121	N/A
Superfamily	N/A	N/A