Product Description: DNA mismatch repair protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0000228 | nuclear chromosome |
| Component | GO:0000795 | synaptonemal complex |
| Function | GO:0008094 | ATP-dependent activity, acting on DNA |
| Process | GO:0000710 | meiotic mismatch repair |
| Process | GO:0007131 | reciprocal meiotic recombination |
| Process | GO:0000712 | resolution of meiotic recombination intermediates |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | possibly expressed | 0.43 | 0.75 |
| Schizont | not expressed | 0.09 | 0.95 |
| Gametocyte | not expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1405400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.847 | #Insertions: 9
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1036800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1036800)
Modification: Disrupted | RMgm-2899
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM40
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 100 | 47 | 121 |
| disruptive | 24 | 155 | 107 | 254 |
| missense | 22 | 151 | 106 | 231 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 182 | 69 | 138 |
| disruptive | 55 | 362 | 202 | 370 |
| missense | 43 | 318 | 180 | 279 |
PlasmoDB Total SNPs: 211
Non-coding: 114 | Synonymous: 58 | Nonsynonymous: 39 | Stop Codon: 0
Protein Length: 1515 | Molecular Weight (kDa): 179.831
UniProt ID(s): Q8IM40
PDB ID(s): None
Isoelectric Point: 8.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| InterPro | IPR007695 | DNA mismatch repair protein MutS-like, N-terminal |
| InterPro | IPR016151 | DNA mismatch repair protein MutS, N-terminal |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR035901 | GIY-YIG endonuclease superfamily |
| PFam | PF01624 | DNA mismatch repair protein MutS-like, N-terminal |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF55271 | DNA mismatch repair protein MutS, N-terminal |
| Superfamily | SSF82771 | GIY-YIG endonuclease superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 38315739 | Nonhomologous tails direct heteroduplex rejection and mismatch correction duringsingle-strand annealing in Saccharomyces cerevisiae | Sapede E, Sugawara N, ..., Haber JE | 10.1371/journal.pgen.1010527 |