PF3D7_1405500 (CBWD1)

Genome location: Pf3D7_14_v3:190,754..192,994(+)

Genome classification: Core

Function and Localization

Product Description: COBW domain-containing protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0000166	nucleotide binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.48	0.78
Trophozoite	expressed	0.62	0.67
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.51	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1405500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.345 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM39

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100509

Most Similar Human Ortholog: A0A0B4J2F1

TM-align score: 0.79 | RMSD: 3.22

Seq Identity: 0.26 | Length: 326 / 575

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000136682	COBW domain containing 2
ENSG00000147996	COBW domain containing 5
ENSG00000172785	COBW domain containing 1
ENSG00000196873	COBW domain containing 3
ENSG00000215126	COBW domain containing 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	24	15	41
disruptive	12	86	39	121
missense	11	77	37	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	62	18	39
disruptive	34	183	103	182
missense	25	155	83	106

PlasmoDB Total SNPs: 50

Non-coding: 4 | Synonymous: 29 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 575 | Molecular Weight (kDa): 67.881

UniProt ID(s): Q8IM39

PDB ID(s): None

Isoelectric Point: 6.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003495	CobW/HypB/UreG, nucleotide-binding domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF02492	CobW/HypB/UreG, nucleotide-binding domain
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase