PF3D7_1405700

Genome location: Pf3D7_14_v3:196,106..199,602(-)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.24	0.88
Trophozoite	expressed	0.32	0.80
Schizont	expressed	0.61	0.68
Gametocyte	expressed	0.54	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1405700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.241 | MFS: -2.592 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM37

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132846

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	37	21	48
disruptive	25	129	43	138
missense	19	114	41	120

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	70	38	44
disruptive	57	259	102	199
missense	39	207	87	121

PlasmoDB Total SNPs: 177

Non-coding: 56 | Synonymous: 71 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 719 | Molecular Weight (kDa): 82.949

UniProt ID(s): Q8IM37

PDB ID(s): None

Isoelectric Point: 4.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
PFam	PF13639	Zinc finger, RING-type
Superfamily	SSF57850	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104