Product Description: ribosome biogenesis protein BOP1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070545 | PeBoW complex |
| Component | GO:0030687 | preribosome, large subunit precursor |
| Function | GO:0043021 | ribonucleoprotein complex binding |
| Process | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.88 | 0.29 |
| Trophozoite | expressed | 1.00 | 0.50 |
| Schizont | possibly expressed | 0.37 | 0.80 |
| Gametocyte | possibly expressed | 1.05 | 0.47 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1405800
Resistome Missense Mutations: Y193F
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.643 | MFS: -2.42 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1036400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1036400)
Modification: Disrupted | RMgm-2897
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM36
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102525
Most Similar Human Ortholog: Q14137
TM-align score: 0.60 | RMSD: 3.69
Seq Identity: 0.22 | Length: 496 / 966
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000261236 | BOP1 ribosomal biogenesis factor |
| ENSG00000285301 | BOP1 ribosomal biogenesis factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 57 | 32 | 79 |
| disruptive | 25 | 170 | 75 | 205 |
| missense | 19 | 153 | 71 | 177 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 119 | 54 | 74 |
| disruptive | 53 | 357 | 159 | 316 |
| missense | 37 | 301 | 136 | 218 |
PlasmoDB Total SNPs: 228
Non-coding: 146 | Synonymous: 52 | Nonsynonymous: 30 | Stop Codon: 0
Protein Length: 966 | Molecular Weight (kDa): 114.239
UniProt ID(s): Q8IM36
PDB ID(s): None
Isoelectric Point: 6.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR012953 | BOP1, N-terminal domain |
| InterPro | IPR028598 | WD repeat BOP1/Erb1 |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF08145 | BOP1, N-terminal domain |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |