About Gene List

PF3D7_1405900

Genome location: Pf3D7_14_v3:204,930..209,333(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0003723 RNA binding
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.19 0.49
Trophozoite expressed 0.76 0.59
Schizont expressed 0.27 0.83
Gametocyte expressed 0.85 0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1405900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.987 | MFS: -2.743 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A153

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533112

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 55 31 82
disruptive 43 197 100 239
missense 21 155 86 192

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 19 103 51 101
disruptive 113 406 165 354
missense 46 321 128 239

PlasmoDB Total SNPs: 310

Non-coding: 116 | Synonymous: 117 | Nonsynonymous: 77 | Stop Codon: 0

Protein Information

Protein Length: 1109 | Molecular Weight (kDa): 130.818

UniProt ID(s): A0A144A153

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000504 RNA recognition motif domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF00076 RNA recognition motif domain
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097