Product Description: RNA-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005737 | cytoplasm |
Component | GO:0005634 | nucleus |
Function | GO:0003723 | RNA binding |
Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 1.19 | 0.49 |
Trophozoite | expressed | 0.76 | 0.59 |
Schizont | expressed | 0.27 | 0.83 |
Gametocyte | expressed | 0.85 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1405900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.987 | MFS: -2.743 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A153
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 7 | 55 | 31 | 82 |
disruptive | 43 | 197 | 100 | 239 |
missense | 21 | 155 | 86 | 192 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 19 | 103 | 51 | 101 |
disruptive | 113 | 406 | 165 | 354 |
missense | 46 | 321 | 128 | 239 |
PlasmoDB Total SNPs: 310
Non-coding: 116 | Synonymous: 117 | Nonsynonymous: 77 | Stop Codon: 0
Protein Length: 1109 | Molecular Weight (kDa): 130.818
UniProt ID(s): A0A144A153
PDB ID(s): None
Isoelectric Point: 9.52
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000504 | RNA recognition motif domain |
InterPro | IPR035979 | RNA-binding domain superfamily |
PFam | PF00076 | RNA recognition motif domain |
Superfamily | SSF54928 | RNA-binding domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |