PF3D7_1406100

Genome location: Pf3D7_14_v3:211,139..215,915(-)

Genome classification: Core

Function and Localization

Product Description: tubby domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.23	0.89
Trophozoite	possibly expressed	0.45	0.73
Schizont	expressed	0.54	0.68
Gametocyte	not expressed	0.55	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1406100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.579 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM33

"Best" AlphaFill ligand hit: I3P (d-myo-inositol-1,4,5-triphosphate, Local RMSD=0.39) with 3C5N (Global RMSD=14.13)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101683

Most Similar Human Ortholog: F5H7B9

TM-align score: 0.72 | RMSD: 1.61

Seq Identity: 0.33 | Length: 109 / 1361

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000078246	TUB like protein 3
ENSG00000112041	TUB like protein 1
ENSG00000166402	TUB bipartite transcription factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	71	32	67
disruptive	66	224	155	316
missense	44	189	132	259

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	133	58	84
disruptive	126	549	191	438
missense	77	432	149	308

PlasmoDB Total SNPs: 215

Non-coding: 27 | Synonymous: 85 | Nonsynonymous: 103 | Stop Codon: 0

Protein Information

Protein Length: 1361 | Molecular Weight (kDa): 162.418

UniProt ID(s): Q8IM33

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000007	Tubby, C-terminal
InterPro	IPR025659	Tubby-like, C-terminal
PFam	PF01167	Tubby, C-terminal
Superfamily	SSF54518	Tubby-like, C-terminal