Product Description: vacuolar protein sorting-associated protein 29
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005768 | endosome |
| Component | GO:0030904 | retromer complex |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0042147 | retrograde transport, endosome to Golgi |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.28 | 0.82 |
| Schizont | expressed | 0.15 | 0.89 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1406700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.185 | MFS: -2.635 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1035500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM27
"Best" AlphaFill ligand hit: O4B (1,4,7,10,13,16-hexaoxacyclooctadecane, Local RMSD=0.33) with 6XS9 (Global RMSD=1.07)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101343
Most Similar Human Ortholog: Q9UBQ0
TM-align score: 0.97 | RMSD: 1.02
Seq Identity: 0.47 | Length: 182 / 194
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000111237 | VPS29 retromer complex component |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 92
Non-coding: 84 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 194 | Molecular Weight (kDa): 21.774
UniProt ID(s): Q8IM27
PDB ID(s): None
Isoelectric Point: 5.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000979 | Phosphodiesterase MJ0936/Vps29 |
| InterPro | IPR024654 | Calcineurin-like phosphoesterase domain, lpxH-type |
| InterPro | IPR028661 | Vacuolar protein sorting-associated protein 29 |
| PFam | PF12850 | Calcineurin-like phosphoesterase domain, lpxH-type |
| Superfamily | SSF56300 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 26690372 | Expression, purification and characterization of Plasmodium falciparum vacuolarprotein sorting 29. | Iqbal MS, Siddiqui AA, ..., Bandyopadhyay U | 10.1016/j.pep.2015.12.004 |
| 29654975 | Detection of retromer assembly in Plasmodium falciparum by immunosensing coupledto Surface Plasmon Resonance. | Iqbal MS, Siddiqui AA, ..., Bandyopadhyay U | https://pubmed.ncbi.nlm.nih.gov/29654975/ |