Product Description: LCCL domain-containing protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.13.11.12 (Linoleate 13S-lipoxygenase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0015030 | Cajal body |
| Component | GO:0031428 | box C/D RNP complex |
| Component | GO:0044312 | crystalloid |
| Component | GO:0032040 | small-subunit processome |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0003723 | RNA binding |
| Function | GO:1990259 | histone-glutamine methyltransferase activity |
| Function | GO:0044877 | protein-containing complex binding |
| Function | GO:0008649 | rRNA methyltransferase activity |
| Process | GO:0000494 | box C/D RNA 3'-end processing |
| Process | GO:1990258 | histone glutamine methylation |
| Process | GO:0031167 | rRNA methylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.76 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1407000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.785 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1035200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1035200)
Modification: Mutated | RMgm-4138
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM24
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.13.11.12 | linoleate 13S-lipoxygenase | NDGArutinTroloxeugenolapigenincyanidincatechinpeonidinPD146176estragolstylosinquercetin... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 64 | 43 | 78 |
| disruptive | 7 | 64 | 60 | 158 |
| missense | 7 | 64 | 59 | 148 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 129 | 49 | 90 |
| disruptive | 17 | 159 | 111 | 221 |
| missense | 14 | 145 | 104 | 183 |
PlasmoDB Total SNPs: 56
Non-coding: 0 | Synonymous: 42 | Nonsynonymous: 14 | Stop Codon: 0
Protein Length: 1272 | Molecular Weight (kDa): 142.785
UniProt ID(s): Q8IM24
PDB ID(s): None
Isoelectric Point: 7.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001024 | PLAT/LH2 domain |
| InterPro | IPR001190 | SRCR domain |
| InterPro | IPR004043 | LCCL domain |
| InterPro | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| InterPro | IPR017229 | Multidomain scavenger receptor-like protein PxSR |
| InterPro | IPR017448 | SRCR-like domain |
| InterPro | IPR036392 | PLAT/LH2 domain superfamily |
| InterPro | IPR036609 | LCCL domain superfamily |
| InterPro | IPR036772 | SRCR-like domain superfamily |
| PFam | PF00530 | SRCR domain |
| PFam | PF01477 | PLAT/LH2 domain |
| PFam | PF03815 | LCCL domain |
| PFam | PF13385 | |
| Superfamily | SSF49723 | PLAT/LH2 domain superfamily |
| Superfamily | SSF49899 | Concanavalin A-like lectin/glucanase domain superfamily |
| Superfamily | SSF56487 | SRCR-like domain superfamily |
| Superfamily | SSF69848 | LCCL domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15184503 | A multidomain adhesion protein family expressed in Plasmodium falciparum isessential for transmission to the mosquito. | Pradel G, Hayton K, ..., Templeton TJ | 10.1084/jem.20031274 |
| 18452513 | PbSR is synthesized in macrogametocytes and involved in formation of the malariacrystalloids. | Carter V, Shimizu S, Arai M, Dessens JT | 10.1111/j.1365-2958.2008.06254.x |
| 19304662 | Sexual stage adhesion proteins form multi-protein complexes in the malariaparasite Plasmodium falciparum. | Simon N, Scholz SM, ..., Pradel G | 10.1074/jbc.M808472200 |