Product Description: rRNA 2'-O-methyltransferase fibrillarin, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0015030 | Cajal body |
| Component | GO:0031428 | box C/D RNP complex |
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Component | GO:0032040 | small-subunit processome |
| Component | GO:0005732 | sno(s)RNA-containing ribonucleoprotein complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:1990259 | histone-glutamine methyltransferase activity |
| Function | GO:0008649 | rRNA methyltransferase activity |
| Process | GO:0000494 | box C/D RNA 3'-end processing |
| Process | GO:1990258 | histone glutamine methylation |
| Process | GO:0031167 | rRNA methylation |
| Process | GO:0006364 | rRNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.02 | 0.54 |
| Trophozoite | expressed | 0.82 | 0.57 |
| Schizont | expressed | 0.15 | 0.91 |
| Gametocyte | expressed | 0.56 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1407100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.902 | MFS: -2.36 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1035100)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1035100)
Modification: Other | RMgm-410
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM23
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=0.60) with 7SE7 (Global RMSD=0.95)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100868
Most Similar Human Ortholog: M0R299
TM-align score: 0.99 | RMSD: 0.60
Seq Identity: 0.69 | Length: 229 / 318
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105202 | fibrillarin |
| ENSG00000188573 | fibrillarin like 1 |
| ENSG00000280548 | fibrillarin |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 32 | 15 | 23 |
| disruptive | 26 | 54 | 23 | 49 |
| missense | 3 | 20 | 10 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 52 | 11 | 33 |
| disruptive | 35 | 83 | 28 | 73 |
| missense | 5 | 35 | 15 | 41 |
PlasmoDB Total SNPs: 132
Non-coding: 88 | Synonymous: 34 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 318 | Molecular Weight (kDa): 34.129
PDB ID(s): None
Isoelectric Point: 10.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000692 | Fibrillarin |
| InterPro | IPR020813 | Fibrillarin, conserved site |
| InterPro | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| PFam | PF01269 | Fibrillarin |
| Superfamily | SSF53335 | S-adenosyl-L-methionine-dependent methyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 18525026 | Differential association of Orc1 and Sir2 proteins to telomeric domains inPlasmodium falciparum. | Mancio-Silva L, Rojas-Meza AP, ..., Hernandez-Rivas R | 10.1242/jcs.026427 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31872112 | Plasmodium falciparum DDX31 is DNA helicase localized in nucleolus. | Yasmin R, Chauhan M, Sourabh S, Tuteja R | 10.1016/j.heliyon.2019.e02905 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 33866806 | Protein aggregation and the evolution of stress resistance in clinical yeast | Chen YR, Ziv I, ..., Jarosz DF | 10.1098/rstb.2020.0127 |
| 31895625 | A Drug Repurposing and Protein-Protein Interaction Network Study ofRibosomopathies Using Yeast as a Model System | Ertekin E, Gencturk E, Kasim M, Ulgen KO | 10.1089/omi.2019.0096 |
| 31506176 | Def1 mediates the degradation of excess nucleolar protein Nop1 in budding yeast | Morshed S, Mochida T, ..., Ushimaru T | 10.1016/j.bbrc.2019.09.002 |
| 29988094 | Genome-wide SWAp-Tag yeast libraries for proteome exploration | Weill U, Yofe I, ..., Schuldiner M | 10.1038/s41592-018-0044-9 |
| 30345388 | Mapping targets for small nucleolar RNAs in yeast | Dudnakova T, Dunn-Davies H, Peters R, Tollervey D | 10.12688/wellcomeopenres.14735.2 |
| 31756331 | Crosstalk of Phosphorylation and Arginine Methylation in Disordered SRGG Repeatsof Saccharomycescerevisiae Fibrillarin and Its Association with NucleolarLocalization | Smith DL, Erce MA, ..., Wilkins MR | 10.1016/j.jmb.2019.11.006 |