PF3D7_1407200

Genome location: Pf3D7_14_v3:260,615..262,717(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.26	0.87
Trophozoite	not expressed	0.17	0.89
Schizont	not expressed	0.11	0.93
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1407200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.163 | MFS: -3.332 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM22

"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=1.81) with 7V50 (Global RMSD=21.76)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111096

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	11	8	18
disruptive	6	22	10	31
missense	5	21	9	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	26	13	23
disruptive	11	41	20	60
missense	7	36	18	45

PlasmoDB Total SNPs: 97

Non-coding: 79 | Synonymous: 11 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 289 | Molecular Weight (kDa): 34.412

UniProt ID(s): Q8IM22

PDB ID(s): None

Isoelectric Point: 8.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A