About Gene List

PF3D7_1407300 (PRP38B)

Genome location: Pf3D7_14_v3:263,070..267,617(+)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA-splicing factor 38B, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0071011 precatalytic spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.68 0.67
Trophozoite expressed 0.65 0.63
Schizont expressed 0.26 0.83
Gametocyte expressed 0.68 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1407300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.242 | MFS: -2.646 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1034900)

  • Relative Growth Rate: 0.28 ± 0.18
  • Confidence: 4.84

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1034900)

Modification: Disrupted | RMgm-2888

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM21

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104096

Most Similar Human Ortholog: Q5VTL8

TM-align score: 0.37 | RMSD: 4.28

Seq Identity: 0.34 | Length: 230 / 690

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000134186 pre-mRNA processing factor 38B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 47 26 53
disruptive 14 60 41 120
missense 11 58 39 111

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 19 86 35 49
disruptive 29 144 77 190
missense 22 133 68 149

PlasmoDB Total SNPs: 254

Non-coding: 202 | Synonymous: 37 | Nonsynonymous: 14 | Stop Codon: 1

Protein Information

Protein Length: 690 | Molecular Weight (kDa): 81.763

UniProt ID(s): Q8IM21

PDB ID(s): None

Isoelectric Point: 10.26

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005037 Pre-mRNA-splicing factor 38
PFam PF03371 Pre-mRNA-splicing factor 38
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104