PF3D7_1407400

Genome location: Pf3D7_14_v3:267,209..269,438(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.25	0.87
Trophozoite	not expressed	0.54	0.68
Schizont	possibly expressed	0.21	0.85
Gametocyte	not expressed	0.83	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1407400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.185 | MFS: -2.718 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1034800)

Relative Growth Rate: 1.00 ± 0.15
Confidence: 5.20

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1034800)

Modification: Disrupted | RMgm-2887

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM20

"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=1.60) with 6KCK (Global RMSD=27.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533709

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 200

Non-coding: 177 | Synonymous: 12 | Nonsynonymous: 10 | Stop Codon: 1

Protein Information

Protein Length: 194 | Molecular Weight (kDa): 23.667

UniProt ID(s): Q8IM20

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A