Product Description: multifunctional methyltransferase subunit TRM112, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.32 (Transferred entry: 2.1.1.213, 2.1.1.214, 2.1.1.215 and 2.1.1.216)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0018364 | peptidyl-glutamine methylation |
| Process | GO:0070476 | rRNA (guanine-N7)-methylation |
| Process | GO:0042273 | ribosomal large subunit biogenesis |
| Process | GO:0042274 | ribosomal small subunit biogenesis |
| Process | GO:0030488 | tRNA methylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.34 | 0.83 |
| Trophozoite | expressed | 0.44 | 0.74 |
| Schizont | expressed | 0.10 | 0.93 |
| Gametocyte | expressed | 0.55 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1407500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.142 | MFS: -3.085 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1034700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM19
"Best" AlphaFill ligand hit: PYR (pyruvic acid, Local RMSD=6.60) with 4JGO (Global RMSD=14.84)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.1.32 | tRNA (guanine-N2-)-methyltransferase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102098
Most Similar Human Ortholog: Q9UI30
TM-align score: 0.86 | RMSD: 1.65
Seq Identity: 0.35 | Length: 120 / 125
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000173113 | tRNA methyltransferase subunit 11-2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 107
Non-coding: 94 | Synonymous: 3 | Nonsynonymous: 7 | Stop Codon: 3
Protein Length: 125 | Molecular Weight (kDa): 14.234
UniProt ID(s): Q8IM19
PDB ID(s): None
Isoelectric Point: 5.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005651 | Trm112-like |
| InterPro | IPR039127 | Multifunctional methyltransferase subunit Trm112 |
| PFam | PF03966 | Trm112-like |
| Superfamily | SSF158997 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29846136 | Intracellular mechanism by which arsenite activates the yeast stress MAPK Hog1 | Lee J, Levin DE | 10.1091/mbc.E18-03-0185 |