PF3D7_1407600

Genome location: Pf3D7_14_v3:271,014..277,357(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.45	0.80
Trophozoite	expressed	0.30	0.83
Schizont	possibly expressed	0.14	0.92
Gametocyte	not expressed	0.18	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1407600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.443 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM18

"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.60) with 4S0F (Global RMSD=32.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532735

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	19	87	48	106
disruptive	115	384	212	441
missense	80	327	186	386

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	33	165	69	146
disruptive	236	713	285	556
missense	151	590	236	438

PlasmoDB Total SNPs: 233

Non-coding: 4 | Synonymous: 107 | Nonsynonymous: 121 | Stop Codon: 1

Protein Information

Protein Length: 2033 | Molecular Weight (kDa): 241.131

UniProt ID(s): Q8IM18

PDB ID(s): None

Isoelectric Point: 10.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A