About Gene List

PF3D7_1407700

Genome location: Pf3D7_14_v3:279,176..280,673(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite not expressed 0.01 0.99
Schizont not expressed 0.01 0.99
Gametocyte not expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1407700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.284 | MFS: -2.8 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1034500)

  • Relative Growth Rate: 0.99 ± 0.09
  • Confidence: 6.23

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1034500)

Modification: Disrupted | RMgm-2884

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM17

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215374

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 19 13 27
disruptive 16 12 21 48
missense 16 11 20 43

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 39 15 27
disruptive 21 53 17 94
missense 18 49 13 73

PlasmoDB Total SNPs: 77

Non-coding: 48 | Synonymous: 18 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 406 | Molecular Weight (kDa): 47.264

UniProt ID(s): Q8IM17

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23027733 Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments usingMORN1. Lorestani A, Ivey FD, ..., Gubbels MJ 10.1002/cm.21077