Product Description: AP2 domain transcription factor AP2-G2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000792 | heterochromatin |
| Component | GO:0005634 | nucleus |
| Function | GO:0003700 | DNA-binding transcription factor activity |
| Function | GO:0005515 | protein binding |
| Function | GO:0043565 | sequence-specific DNA binding |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.17 | 0.50 |
| Trophozoite | expressed | 0.88 | 0.55 |
| Schizont | expressed | 0.21 | 0.87 |
| Gametocyte | expressed | 0.95 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1408200
Resistome Missense Mutations: N465H
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 7 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.866 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_1036700)
Modification: Tagged | RMgm-4396
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM14
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 97 | 69 | 109 |
| disruptive | 113 | 343 | 150 | 334 |
| missense | 67 | 249 | 122 | 266 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 41 | 210 | 74 | 124 |
| disruptive | 229 | 642 | 270 | 547 |
| missense | 128 | 471 | 210 | 328 |
PlasmoDB Total SNPs: 380
Non-coding: 65 | Synonymous: 158 | Nonsynonymous: 157 | Stop Codon: 0
Protein Length: 1702 | Molecular Weight (kDa): 200.796
UniProt ID(s): Q8IM14
PDB ID(s): None
Isoelectric Point: 5.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001471 | AP2/ERF domain |
| PFam | PF00847 | AP2/ERF domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21060817 | Identification and genome-wide prediction of DNA binding specificities for theApiAP2 family of regulators from the malaria parasite. | Campbell TL, De Silva EK, ..., Llinas M | 10.1371/journal.ppat.1001165 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 33368818 | The PfAP2-G2 transcription factor is a critical regulator of gametocytematuration. | Singh S, Santos JM, ..., Llinas M | 10.1111/mmi.14676 |
| 33537025 | PfAP2-G2 Is Associated to Production and Maturation of Gametocytes in Plasmodiumfalciparum via Regulating the Expression of PfMDV-1. | Xu Y, Qiao D, ..., Cao Y | 10.3389/fmicb.2020.631444 |
| 35288749 | Genome-wide landscape of ApiAP2 transcription factors reveals aheterochromatin-associated regulatory network during Plasmodium falciparumblood-stage development. | Shang X, Wang C, ..., Zhang Q | 10.1093/nar/gkac176 |
| 35051657 | A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual andSexual Development | von Gruning H, Coradin M, ..., Birkholtz LM | 10.1016/j.mcpro.2022.100199 |
| 34119684 | Mechanisms of triggering malaria gametocytogenesis by AP2-G | Yuda M, Kaneko I, ..., Nishi T | 10.1016/j.parint.2021.102403 |
| 28081440 | A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting TranscriptionalRegulators Controlling the Plasmodium Life Cycle | Modrzynska K, Pfander C, ..., Billker O | 10.1016/j.chom.2016.12.003 |
| 26417110 | Global transcriptional repression: An initial and essential step for Plasmodiumsexual development | Yuda M, Iwanaga S, Kaneko I, Kato T | 10.1073/pnas.1504389112 |