PF3D7_1408300

Genome location: Pf3D7_14_v3:312,569..313,296(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1408300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.989 | MFS: -1.781 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1V6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532358

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	1	7
disruptive	5	22	7	47
missense	4	22	7	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	18	2	12
disruptive	10	69	24	53
missense	8	58	19	35

PlasmoDB Total SNPs: 42

Non-coding: 29 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 150 | Molecular Weight (kDa): 17.953

UniProt ID(s): A0A144A1V6

PDB ID(s): None

Isoelectric Point: 10.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A