About Gene List

PF3D7_1408500

Genome location: Pf3D7_14_v3:319,847..321,454(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.63 0.70
Trophozoite not expressed 0.73 0.61
Schizont possibly expressed 0.10 0.94
Gametocyte not expressed 0.42 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1408500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.186 | MFS: -3.339 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1034000)

  • Relative Growth Rate: 0.12 ± 0.09
  • Confidence: 6.23

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM11

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533530

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 91

Non-coding: 76 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 195 | Molecular Weight (kDa): 22.966

UniProt ID(s): Q8IM11

PDB ID(s): None

Isoelectric Point: 10.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108