Product Description: 40S ribosomal protein S8e, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.15 | 0.26 |
| Trophozoite | expressed | 2.51 | 0.12 |
| Schizont | expressed | 0.55 | 0.70 |
| Gametocyte | expressed | 1.21 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1408600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -2.487 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1033900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM10
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100802
Most Similar Human Ortholog: P62241
TM-align score: 0.91 | RMSD: 1.91
Seq Identity: 0.59 | Length: 200 / 218
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000142937 | ribosomal protein S8 |
| ENSG00000288164 | unknown |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 15 | 7 | 22 |
| disruptive | 1 | 7 | 3 | 12 |
| missense | 1 | 7 | 2 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 31 | 14 | 19 |
| disruptive | 4 | 30 | 22 | 62 |
| missense | 2 | 18 | 17 | 34 |
PlasmoDB Total SNPs: 87
Non-coding: 83 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 218 | Molecular Weight (kDa): 25.051
UniProt ID(s): Q8IM10
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001047 | Ribosomal protein S8e |
| InterPro | IPR022309 | Ribosomal protein S8e/ribosomal biogenesis NSA2 |
| PFam | PF01201 | Ribosomal protein S8e/ribosomal biogenesis NSA2 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |