PF3D7_1408700

Genome location: Pf3D7_14_v3:324,334..347,119(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding
Function	GO:0004843	thiol-dependent deubiquitinase
Process	GO:0009657	plastid organization
Process	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.58	0.39
Trophozoite	expressed	1.98	0.24
Schizont	expressed	1.76	0.37
Gametocyte	expressed	1.98	0.19

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1408700

Resistome Missense Mutations: K2408R

Resistome Compounds with Missense Mutations: MMV084978

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.985 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1033800)

Relative Growth Rate: 0.07 ± 0.12
Confidence: 5.60

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146373

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	81	448	228	550
disruptive	244	1071	595	1296
missense	174	960	549	1140

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	143	897	367	581
disruptive	473	2168	991	1931
missense	326	1869	861	1438

PlasmoDB Total SNPs: 784

Non-coding: 106 | Synonymous: 406 | Nonsynonymous: 272 | Stop Codon: 0

Protein Information

Protein Length: 7182 | Molecular Weight (kDa): 851.885

UniProt ID(s): Q8IM09

PDB ID(s): None

Isoelectric Point: 9.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022099	Protein of unknown function DUF3638
InterPro	IPR022105	Protein of unknown function DUF3645
PFam	PF12340	Protein of unknown function DUF3638
PFam	PF12359	Protein of unknown function DUF3645
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30726238	A mutagenesis screen for essential plastid biogenesis genes in human malariaparasites.	Tang Y, Meister TR, ..., Yeh E	10.1371/journal.pbio.3000136