PF3D7_1408800

Genome location: Pf3D7_14_v3:348,831..350,857(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.41	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1408800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.981 | MFS: -2.954 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM08

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532486

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	23	7	21
disruptive	10	28	12	49
missense	7	28	12	39

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	40	14	19
disruptive	20	71	36	65
missense	12	60	27	46

PlasmoDB Total SNPs: 73

Non-coding: 53 | Synonymous: 12 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 297 | Molecular Weight (kDa): 34.895

UniProt ID(s): Q8IM08

PDB ID(s): None

Isoelectric Point: 9.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A