PF3D7_1409000

Genome location: Pf3D7_14_v3:352,521..355,754(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0005634	nucleus
Component	GO:0043527	tRNA methyltransferase complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.14	0.93
Trophozoite	expressed	0.29	0.82
Schizont	expressed	0.05	0.97
Gametocyte	expressed	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1409000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.732 | MFS: -2.933 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM06

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532315

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	20	16	40
disruptive	20	82	54	111
missense	16	73	52	102

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	47	29	41
disruptive	43	187	84	179
missense	28	159	71	132

PlasmoDB Total SNPs: 235

Non-coding: 155 | Synonymous: 38 | Nonsynonymous: 42 | Stop Codon: 0

Protein Information

Protein Length: 566 | Molecular Weight (kDa): 67.203

UniProt ID(s): Q8IM06

PDB ID(s): None

Isoelectric Point: 4.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR028884	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily