Product Description: aldo-keto reductase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 1.1.1.21 (Aldose reductase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005829 | cytosol |
| Function | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| Function | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| Function | GO:0016491 | oxidoreductase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 0.79 | 0.59 |
| Schizont | expressed | 0.37 | 0.80 |
| Gametocyte | expressed | 0.74 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1409100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.15 | MFS: -2.791 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1033400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM05
"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=1.28) with 1PZ1 (Global RMSD=7.11)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.1.1.21 | aldose reductase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 71 | 42 | 95 |
| disruptive | 57 | 158 | 92 | 203 |
| missense | 35 | 121 | 84 | 163 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 154 | 66 | 93 |
| disruptive | 115 | 332 | 140 | 312 |
| missense | 66 | 254 | 113 | 205 |
PlasmoDB Total SNPs: 251
Non-coding: 92 | Synonymous: 90 | Nonsynonymous: 69 | Stop Codon: 0
Protein Length: 1212 | Molecular Weight (kDa): 143.353
UniProt ID(s): Q8IM05
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR023210 | NADP-dependent oxidoreductase domain |
| InterPro | IPR036812 | NADP-dependent oxidoreductase domain superfamily |
| PFam | PF00248 | NADP-dependent oxidoreductase domain |
| Superfamily | SSF51430 | NADP-dependent oxidoreductase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |