PF3D7_1409200

Genome location: Pf3D7_14_v3:360,234..362,579(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	nd	nd
Trophozoite	not expressed	nd	nd
Schizont	not expressed	nd	nd
Gametocyte	not expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1409200.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.962 | MFS: 0.319 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1033300)

Relative Growth Rate: 0.98 ± 0.21
Confidence: 4.47

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1033300)

Modification: Disrupted | RMgm-2875

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1W9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533304

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	1	3	14
disruptive	5	28	11	39
missense	5	28	10	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	10	10	17
disruptive	7	56	27	68
missense	7	45	25	46

PlasmoDB Total SNPs: 107

Non-coding: 87 | Synonymous: 13 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 198 | Molecular Weight (kDa): 23.555

UniProt ID(s): A0A144A1W9, Q8IM04

PDB ID(s): None

Isoelectric Point: 9.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A