About Gene List

PF3D7_1409400

Genome location: Pf3D7_14_v3:365,269..367,978(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite possibly expressed 0.23 0.85
Schizont expressed 1.14 0.45
Gametocyte expressed 0.68 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1409400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -3 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1033100)

  • Relative Growth Rate: 0.17 ± 0.11
  • Confidence: 5.89

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1033100)

Modification: Disrupted | RMgm-495

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM01

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130932

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 1
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 1 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 187

Non-coding: 174 | Synonymous: 11 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 262 | Molecular Weight (kDa): 30.539

UniProt ID(s): Q8IM01

PDB ID(s): None

Isoelectric Point: 8.67

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27128092 Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. Swearingen KE, Lindner SE, ..., Sinnis P 10.1371/journal.ppat.1005606