PF3D7_1409600

Genome location: Pf3D7_14_v3:373,950..377,186(+)

Genome classification: Core

Function and Localization

Product Description: histidine phosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0016868	intramolecular transferase activity, phosphotransferases

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.98	0.56
Trophozoite	expressed	0.78	0.57
Schizont	expressed	0.66	0.61
Gametocyte	possibly expressed	0.50	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1409600

Resistome Missense Mutations: T594R

Resistome Compounds with Missense Mutations: MMV982556

Resistome # Samples with Disruptive Mutations: 3 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.961 | MFS: -2.714 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILZ9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112916

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	37	22	51
disruptive	44	95	50	94
missense	30	85	41	74

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	73	34	67
disruptive	74	183	112	184
missense	48	147	82	122

PlasmoDB Total SNPs: 187

Non-coding: 101 | Synonymous: 46 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 768 | Molecular Weight (kDa): 92.748

UniProt ID(s): Q8ILZ9

PDB ID(s): None

Isoelectric Point: 7.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029033	Histidine phosphatase superfamily
PFam	N/A	N/A
Superfamily	SSF53254	Histidine phosphatase superfamily