PF3D7_1409700

Genome location: Pf3D7_14_v3:377,013..380,614(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.28	0.82
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.21	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1409700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.094 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1032800)

Relative Growth Rate: 0.13 ± 0.11
Confidence: 5.72

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A3L0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533230

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	46	20	37
disruptive	17	91	58	171
missense	17	91	56	166

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	77	32	55
disruptive	35	223	125	232
missense	30	204	112	193

PlasmoDB Total SNPs: 160

Non-coding: 88 | Synonymous: 46 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 848 | Molecular Weight (kDa): 102.016

UniProt ID(s): A0A144A3L0

PDB ID(s): None

Isoelectric Point: 9.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21