Product Description: CUGBP Elav-like family member 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043186 | P granule |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | possibly expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1409800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.966 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1032700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1032700)
Modification: Disrupted | RMgm-2871
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILZ7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 35 | 18 | 31 |
| disruptive | 16 | 32 | 22 | 55 |
| missense | 5 | 28 | 17 | 43 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 73 | 19 | 41 |
| disruptive | 20 | 82 | 73 | 157 |
| missense | 7 | 68 | 52 | 114 |
PlasmoDB Total SNPs: 185
Non-coding: 154 | Synonymous: 19 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 514 | Molecular Weight (kDa): 59.275
UniProt ID(s): Q8ILZ7
PDB ID(s): None
Isoelectric Point: 7.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR001202 | WW domain |
| InterPro | IPR002343 | Paraneoplastic encephalomyelitis antigen |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| InterPro | IPR036020 | WW domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF00397 | WW domain |
| Superfamily | SSF51045 | WW domain superfamily |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20169188 | Universal features of post-transcriptional gene regulation are critical forPlasmodium zygote development. | Mair GR, Lasonder E, ..., Waters AP | 10.1371/journal.ppat.1000767 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |