Product Description: CTP synthase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.3.4.2 (CTP synthase (glutamine hydrolyzing))
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0003883 | CTP synthase activity |
| Function | GO:0042802 | identical protein binding |
| Process | GO:0006241 | CTP biosynthetic process |
| Process | GO:0019856 | pyrimidine nucleobase biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.50 | 0.76 |
| Trophozoite | expressed | 0.59 | 0.69 |
| Schizont | not expressed | 0.12 | 0.93 |
| Gametocyte | not expressed | 0.23 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1410200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -2.778 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1032300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILZ3
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.12) with 2AD5 (Global RMSD=4.60)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.3.4.2 | CTP synthase (glutamine hydrolysing) | GTPGDPCTPUTPNEMGMPITPGlnPCMBdCTPHgCl2SO42-... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100470
Most Similar Human Ortholog: A0A3B3ITH9
TM-align score: 0.97 | RMSD: 0.64
Seq Identity: 0.70 | Length: 111 / 858
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000047230 | CTP synthase 2 |
| ENSG00000171793 | CTP synthase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 51 | 28 | 55 |
| disruptive | 19 | 69 | 44 | 103 |
| missense | 9 | 56 | 41 | 88 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 100 | 33 | 58 |
| disruptive | 36 | 153 | 65 | 176 |
| missense | 17 | 126 | 58 | 119 |
PlasmoDB Total SNPs: 218
Non-coding: 149 | Synonymous: 47 | Nonsynonymous: 21 | Stop Codon: 1
Protein Length: 858 | Molecular Weight (kDa): 98.517
UniProt ID(s): Q27725, Q8ILZ3, Q9TX46
PDB ID(s): None
Isoelectric Point: 6.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004468 | CTP synthase |
| InterPro | IPR017456 | CTP synthase, N-terminal |
| InterPro | IPR017926 | Glutamine amidotransferase |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR029062 | Class I glutamine amidotransferase-like |
| PFam | PF00117 | Glutamine amidotransferase |
| PFam | PF06418 | CTP synthase, N-terminal |
| Superfamily | SSF52317 | Class I glutamine amidotransferase-like |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16051382 | Functional expression of the gene encoding cytidine triphosphate synthetase fromPlasmodium falciparum which contains two novel sequences that are potentialantimalarial targets. | Yuan P, Hendriks EF, ..., Stewart TS | 10.1016/j.molbiopara.2005.06.004 |
| 38203781 | Cytoophidia Influence Cell Cycle and Size in Schizosaccharomyces pombe | Deng R, Li YL, Liu JL | 10.3390/ijms25010608 |
| 38073022 | Crude Tieguanyin oolong tea polysaccharides regulate intestinal immune and gutmicroflora in dextran sulfate sodium-induced mice colitis | Zhang Y, Pan Y, ..., Chu Q | 10.1002/jsfa.13206 |