PF3D7_1410300

Genome location: Pf3D7_14_v3:403,607..418,311(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030686	90S preribosome
Component	GO:0005730	nucleolus
Function	GO:0034511	U3 snoRNA binding
Process	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.66	0.71
Trophozoite	expressed	1.53	0.34
Schizont	not expressed	1.30	0.46
Gametocyte	not expressed	1.69	0.29

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1410300

Resistome Missense Mutations: N1545D

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 9 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.289 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1032200)

Modification: Disrupted | RMgm-4251

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112319

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	47	216	131	260
disruptive	170	537	288	718
missense	94	456	252	613

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	89	393	152	302
disruptive	311	1085	459	942
missense	166	892	405	723

PlasmoDB Total SNPs: 707

Non-coding: 83 | Synonymous: 348 | Nonsynonymous: 271 | Stop Codon: 5

Protein Information

Protein Length: 4405 | Molecular Weight (kDa): 526.732

UniProt ID(s): Q25782, Q8ILZ2

PDB ID(s): None

Isoelectric Point: 9.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
PFam	N/A	N/A
Superfamily	SSF141571	Quinoprotein alcohol dehydrogenase-like superfamily
Superfamily	SSF50998