PF3D7_1410500

Genome location: Pf3D7_14_v3:423,495..424,842(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.25	0.84
Schizont	expressed	0.03	0.98
Gametocyte	not expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1410500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.172 | MFS: -3.142 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1032000)

Relative Growth Rate: 0.06 ± 0.06
Confidence: 6.95

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILZ0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533259

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	1
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 68

Non-coding: 62 | Synonymous: 2 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 133 | Molecular Weight (kDa): 15.598

UniProt ID(s): Q8ILZ0

PDB ID(s): None

Isoelectric Point: 11.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A