About Gene List

PF3D7_1410800

Genome location: Pf3D7_14_v3:432,899..435,698(+)

Genome classification: Core

Function and Localization

Product Description: ankyrin-repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.02 0.99
Schizont expressed 0.32 0.79
Gametocyte expressed 0.10 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1410800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.272 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1031700)

  • Relative Growth Rate: 0.79 ± 0.14
  • Confidence: 5.29

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1031700)

Modification: Disrupted | RMgm-2865

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILY7

"Best" AlphaFill ligand hit: 25A (5'-o-monophosphoryladenylyl(2'->5')adenylyl(2'->5')adenosine, Local RMSD=2.78) with 4G8L (Global RMSD=3.17)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160754

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 9 1 14
disruptive 0 4 4 12
missense 0 4 4 12

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 15 10 18
disruptive 0 17 11 35
missense 0 11 10 29

PlasmoDB Total SNPs: 156

Non-coding: 142 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 172 | Molecular Weight (kDa): 19.514

UniProt ID(s): Q8ILY7

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036770 Ankyrin repeat-containing domain superfamily
PFam PF13857 N/A
Superfamily SSF48403 Ankyrin repeat-containing domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104