PF3D7_1410900

Genome location: Pf3D7_14_v3:436,329..440,098(+)

Genome classification: Core

Function and Localization

Product Description: ribosome maturation protein SBDS, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.45	0.78
Trophozoite	possibly expressed	0.66	0.63
Schizont	possibly expressed	0.61	0.63
Gametocyte	possibly expressed	0.61	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1410900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.585 | MFS: -2.379 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILY6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101125

Most Similar Human Ortholog: F8WE72

TM-align score: 0.92 | RMSD: 1.04

Seq Identity: 0.50 | Length: 86 / 638

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000126524	SBDS ribosome maturation factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	34	23	41
disruptive	18	74	63	114
missense	16	66	58	96

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	75	32	50
disruptive	49	195	109	189
missense	38	164	86	110

PlasmoDB Total SNPs: 147

Non-coding: 95 | Synonymous: 26 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 638 | Molecular Weight (kDa): 74.936

UniProt ID(s): Q8ILY6

PDB ID(s): None

Isoelectric Point: 7.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018023	Ribosome maturation protein SBDS, conserved site
InterPro	IPR018978	Ribosome maturation protein SBDS, C-terminal
InterPro	IPR019783	Ribosome maturation protein SBDS, N-terminal
InterPro	IPR036786	Ribosome maturation protein SBDS, N-terminal domain superfamily
InterPro	IPR037188	Ribosome maturation protein Sdo1/SBDS, central domain superfamily
InterPro	IPR039100	Ribosome maturation protein Sdo1/SBDS-like
PFam	PF01172	Ribosome maturation protein SBDS, N-terminal
PFam	PF09377	Ribosome maturation protein SBDS, C-terminal
Superfamily	SSF109728	Ribosome maturation protein Sdo1/SBDS, central domain superfamily
Superfamily	SSF89895	Ribosome maturation protein SBDS, N-terminal domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104