PF3D7_1411000

Genome location: Pf3D7_14_v3:440,206..447,773(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	nd	nd
Trophozoite	not expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1411000.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.493 | #Insertions: 12

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1031500)

Relative Growth Rate: 0.69 ± 0.41
Confidence: 3.18

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1031500)

Modification: Disrupted | RMgm-2864

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILY5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533564

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	100	65	114
disruptive	65	277	173	358
missense	46	244	162	313

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	34	206	76	119
disruptive	143	617	261	558
missense	93	501	234	391

PlasmoDB Total SNPs: 290

Non-coding: 88 | Synonymous: 94 | Nonsynonymous: 108 | Stop Codon: 0

Protein Information

Protein Length: 2054 | Molecular Weight (kDa): 244.605

UniProt ID(s): Q8ILY5

PDB ID(s): None

Isoelectric Point: 8.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A