PF3D7_1411100

Genome location: Pf3D7_14_v3:447,469..451,755(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1411100.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -2.986 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1031400)

Relative Growth Rate: 0.58 ± 0.38
Confidence: 3.31

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1031400)

Modification: Disrupted | RMgm-2863

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILY4

"Best" AlphaFill ligand hit: OPE (phosphoric acid mono-(2-amino-ethyl) ester, Local RMSD=0.53) with 3FI8 (Global RMSD=25.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215376

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 264

Non-coding: 250 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 373 | Molecular Weight (kDa): 44.219

UniProt ID(s): Q8ILY4

PDB ID(s): None

Isoelectric Point: 7.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A