PF3D7_1411300

Genome location: Pf3D7_14_v3:457,646..461,237(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0043231	intracellular membrane-bounded organelle
Component	GO:0031982	vesicle
Function	GO:0030276	clathrin binding
Process	GO:0072318	clathrin coat disassembly
Process	GO:0072583	clathrin-dependent endocytosis
Process	GO:0006898	receptor-mediated endocytosis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.22	0.85
Schizont	expressed	0.25	0.82
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1411300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.229 | MFS: -3.297 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1031200)

Relative Growth Rate: 0.05 ± 0.12
Confidence: 5.61

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILY2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112454

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	28	21	38
disruptive	14	71	43	107
missense	14	68	42	102

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	64	30	28
disruptive	30	163	85	153
missense	27	150	77	113

PlasmoDB Total SNPs: 194

Non-coding: 141 | Synonymous: 31 | Nonsynonymous: 21 | Stop Codon: 1

Protein Information

Protein Length: 568 | Molecular Weight (kDa): 67.348

UniProt ID(s): Q8ILY2

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	N/A	N/A
Superfamily	SSF46565	Chaperone J-domain superfamily