PF3D7_1411500

Genome location: Pf3D7_14_v3:468,631..472,384(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Function	GO:0003723	RNA binding
Process	GO:0042274	ribosomal small subunit biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.80	0.64
Trophozoite	not expressed	0.60	0.68
Schizont	not expressed	0.13	0.93
Gametocyte	not expressed	0.75	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1411500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.185 | MFS: -3.334 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1031000)

Relative Growth Rate: 0.18 ± 0.19
Confidence: 4.72

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1031000)

Modification: Mutated | RMgm-4740

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILY0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532379

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	52	24	53
disruptive	26	144	87	183
missense	21	130	80	166

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	91	33	62
disruptive	71	319	139	287
missense	52	262	109	213

PlasmoDB Total SNPs: 172

Non-coding: 31 | Synonymous: 68 | Nonsynonymous: 73 | Stop Codon: 0

Protein Information

Protein Length: 947 | Molecular Weight (kDa): 113.512

UniProt ID(s): Q8ILY0

PDB ID(s): None

Isoelectric Point: 9.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold