Product Description: GTP-binding protein Obg1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003677 | DNA binding |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0043022 | ribosome binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.21 | 0.86 |
| Schizont | not expressed | 0.04 | 0.98 |
| Gametocyte | not expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1411600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.204 | MFS: -2.741 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A1B2
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.24) with 5M04 (Global RMSD=9.45)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101006
Most Similar Human Ortholog: Q9H4K7
TM-align score: 0.68 | RMSD: 4.08
Seq Identity: 0.23 | Length: 338 / 658
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101181 | mitochondrial ribosome associated GTPase 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 24 | 14 | 33 |
| disruptive | 23 | 100 | 50 | 122 |
| missense | 13 | 72 | 47 | 97 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 54 | 22 | 48 |
| disruptive | 51 | 194 | 99 | 166 |
| missense | 23 | 153 | 74 | 123 |
PlasmoDB Total SNPs: 81
Non-coding: 9 | Synonymous: 33 | Nonsynonymous: 39 | Stop Codon: 0
Protein Length: 658 | Molecular Weight (kDa): 76.989
UniProt ID(s): A0A144A1B2
PDB ID(s): None
Isoelectric Point: 8.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006073 | GTP binding domain |
| InterPro | IPR006169 | GTP1/OBG domain |
| InterPro | IPR015349 | GTP-binding protein OBG, C-terminal |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036346 | GTP-binding protein OBG, C-terminal domain superfamily |
| InterPro | IPR036726 | GTP1/OBG domain superfamily |
| PFam | PF01018 | GTP1/OBG domain |
| PFam | PF01926 | GTP binding domain |
| PFam | PF09269 | GTP-binding protein OBG, C-terminal |
| Superfamily | SSF102741 | GTP-binding protein OBG, C-terminal domain superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF82051 | GTP1/OBG domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29642957 | Characterization of mitochondrion-targeted GTPases in Plasmodium falciparum. | Gupta K, Gupta A, Haider A, Habib S | 10.1017/S0031182018000501 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 8810143 | Effect of inactivation by sunlight on the larvicidal activities of mosquitocidal Bacillus thuringiensis H-14 isolates from Nigerian soils | Obeta JA | https://pubmed.ncbi.nlm.nih.gov/8810143/ |