Product Description: methyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0052907 | 23S rRNA (adenine(1618)-N(6))-methyltransferase activity |
| Process | GO:0070475 | rRNA base methylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.21 | 0.86 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1411700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.981 | MFS: -2.555 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1030800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1030800)
Modification: Disrupted | RMgm-2858
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILX8
"Best" AlphaFill ligand hit: DTU ((2r,3s)-1,4-dimercaptobutane-2,3-diol, Local RMSD=0.75) with 2H00 (Global RMSD=1.87)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102749
Most Similar Human Ortholog: I3L362
TM-align score: 0.87 | RMSD: 2.31
Seq Identity: 0.33 | Length: 163 / 682
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000127804 | methyltransferase like 16 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 28 | 21 | 41 |
| disruptive | 23 | 101 | 62 | 167 |
| missense | 16 | 89 | 58 | 145 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 67 | 32 | 52 |
| disruptive | 48 | 231 | 126 | 207 |
| missense | 30 | 187 | 104 | 151 |
PlasmoDB Total SNPs: 115
Non-coding: 59 | Synonymous: 34 | Nonsynonymous: 22 | Stop Codon: 0
Protein Length: 682 | Molecular Weight (kDa): 81.099
UniProt ID(s): Q8ILX8
PDB ID(s): None
Isoelectric Point: 8.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010286 | METTL16/RlmF family |
| PFam | PF05971 | METTL16/RlmF family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |